Exploration on the Mechanisms of Chinese Herbal Medicine (Golden Thread) for Tuberculosis based on the Focused Network Pharmacology

In order to explore the active ingredient, potential targets, and tuberculosis-related molecular mechanism of Golden thread along with scientific explanations based on method network pharmacology. We retrieved components targets from TCMSP database. The target genes corresponding tuberculosis were screened obtained GeneCards OMIM, disease-drug protein after intersection two. thread's ingredient for was constructed using Cytoscape. String database used protein-protein interaction analysis.Resultly, a total 48 searched in screened, which revealed 14 having good interactions 75 TB-related proteins. pharmacology analysis that biological functions thread–TB mainly included immune response, signal transduction, metabolism, regulation tumor necrosis factor signaling pathways, IL-17 Toll-like receptors HIF-1 pathway, pathways play role intervention TB. To sum up, present work explored different ingredients playing TB multiple pathway characteristics, performed preliminary validation basic pharmacological effects their underlying mechanism, providing novel insights into action